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KMID : 0357919710050010013
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Korean Journal of Pathology
1971 Volume.5 No. 1 p.13 ~ p.17
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The Early Response of Albino Rat Bkin to 3,7-dimethylbenzanthracene
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Abstract
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It is a well known fact that the skin of rats, with a few exceptions, refractory to
polycyclic hydrocarbons.
The authors tried to observe whether or not the response to dimethylbensanthracene
of albino rats which are widely used in various experiments in our country is similar to
that of mice as reported by Mider and Morton (1939) and Clamor and Stowell (1942) in
early changes
It was confirmed that the skin reactions consisted of atrophy of the epidermis,
elongation and proliferation of hair follicles, increased rate of mitotic division and
squamous metaplasia of epithelial cells of the hair follicles, and cystic dilatation of the
skin appendages.
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